Get ready for the highly anticipated Manchester derby, kicking off Fantasy Premier League (FPL) Gameweek 22! But here's where it gets controversial... While both teams have had cup ties since their last Premier League outings, the starting lineups for today's match are a far cry from Gameweek 21. New interim Manchester United boss Michael Carrick makes four alterations, bringing in Bryan Mbeumo and Amad Diallo, who are fresh from the Africa Cup of Nations (AFCON). However, high-profile players like Matheus Cunha and Benjamin Sesko are on the bench, while Harry Maguire and Kobbie Mainoo replace Ayden Heaven and Manuel Ugarte. If the predicted 4-2-3-1 formation is correct, Patrick Dorgu is set for another 'out-of-position' run-out on the wing. Meanwhile, Manchester City's Pep Guardiola has made just one change, with Antoine Semenyo making his first Premier League start for the club. The winger replaces Tijjani Reijnders, while Rodri takes Nico Gonzalez's place in midfield. However, Matheus Nunes is out due to illness, and Rico Lewis gets his first Premier League start since August. Will these changes pay off for either team? Find out when the match kicks off at 12:30 GMT! But here's the part most people miss... Don't forget to check out the lineups and make your FPL picks accordingly. And this is the part most people miss... What do you think about the changes? Agree or disagree? Let us know in the comments!